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This may not fully answer the question, but there are a few videos on youtube that compare the RF equivalent against the EF to see the difference.

Canon RF vs EF Lenses - Which are the Best? | Comparative Review by BorrowLenses

In the video he talks about the flange distance and that in RF-lenses it is closer to the glass, which means eliminating the need for a retro focal element group, which in other terms means less extreme image correction, fewer lens elements and in many cases a sharper image. (The latter I can personally attest to, when comparing my old 24-105 to its RF equivalent) In the video he specifically compares autofocus, sharpness, color rendition, weight and price on the lenses 50mm and 24-105mm to their EF equivalents. (Spoiler: The RF wins in both cases - especially in sharpness - even though the 50mm is quite a bit more expensive)