I am taking photos around 80m altitudes (with Sony RX0) with a moving drone,Shutter Speed is set to 1/1000 to prevent blurs,I want to take sharp images with manual focus,how should I adjust settings ?
You could try a ring-stop lens to increase the DOF; but, it will be at the expense of the exposure. You might have to compensate with the ISO to regain sharpness loss due to vibration.
A ring-stop lens is simply a "washer" (a disk with a hole in the middle.) You can make a few and see which one suits your purposes. It works the same as squinting helps some people who need glasses but refuse to wear them to see detail more clearly. It's an outboard supplementary "aperture ring" in fact.
Use opaque paper (black is suggested) into which you punch a hole. Place the paper over the lens with the hole centred. You may have to tape it in place.
Start with a hole about the size of the aperture when viewed dead-on. How did it work? No? Try one slightly smaller to see if that result is better, and so on.
There will be an optimal size for the hole. Normally, you can get to half the diameter before image artifacts start to accumulate.