I'm getting random blue artifacts, I have tried different monitors, monitor recalibration, sRGB, and I've tried running it on CPU (not the GPU). No luck yet soon as I open it in ANY other program it seems fine. Just does it in camera raw. So far I have only seen this on JPEGs but I'm not sure about other file types.
The blue and red highlights in Adobe Camera Raw or Adobe Lightroom are called the Shadow/Highlight clipping warnings. They are indications of shadow or highlight areas that are lacking detail, meaning they have gone completely black or completely white.
They can be turned on and off using the triangles in the upper corners of the histogram.
Whether or not this is a bad thing is dependent upon whether those areas of the image should be completely black or completely white. Typically you don't want too much of either. Some things like lights or the sun may always clip.
These areas should be checked after making adjustments to exposure, shadows, hightlights, whites, blacks, etc. as each of those adjustments will have an impact on thise clipping levels.
That's the shadow warning of ACR. You also have a highlight warning, which is red.
They indicate black resp. white parts of your image, which are likely under or over exposed.
You can toggle them by clicking on the little triangles top left and right of your histogram.
Also, you can see them increasing or decreasing when you play with the exposure sliders. Usually, you'll want to minimize those parts of the image by "pulling them in" with the exposure controls, except for specular highlights etc.
Those blue areas are indications from ACR that those pixels are underexposed. If you click on two triangles on the top of histogram you will switch this on and off (left for underexposure, right for overexposure). The same can be done by pressing u and o letters