I definitely think Caleb and Mark are on the right track. This look can be recreated with careful lighting and wardrobe selections - more so than it can be with editing. The lighting setup looks like a gridded (or modified in a similar fashion) key light to prevent spill - notice there are no shadows on the backdrop.
Although, to me, it looks like there is a second source of light - maybe just a reflector - if you look at the reflection in his eyes, you can see one small light source (the key light) coming from slightly up and right of centre and a second light source (maybe just a reflector or a small piece of foamcore) a little low and to the left. I would guess the second light is filling the shadows on his face and collar, whereas otherwise the detail on his shirt would be lost and there would be a little bit more of a shadow to the left of the bridge of his nose. You can also see a bit of light inside his hand - again, that would have to come from a little down and left somewhere.
With regard to editing, the low contrast wardrobe and backdrop give it the desaturated look (think of how neutrally a grey suit and grey backdrop would reflect light).. the rest is probably done by enhancing the detail in lightroom and probably by using an aperture somewhere around 5.6 (his hair is crystal clear, but his ear starts to blur a bit... depends on focal length, etc... but I'd guess an 85mm at f4 or 5.6... could be way off though).
At the end of the day, this look was definitely achieved using lights and wardrobe, editing only enhances it.